Hygeia Therpaeutics, Inc.

 

HYG-102

Rationale for a safer topical estrogen

Estrogens are steroid hormones that support skin health by maintaining skin thickness, moisture content, and elasticity. The profound effects of estrogens on skin were known long before it was discovered that estrogen receptors are present in epithelial tissues but most abundant in facial skin and the uterus.

Decades after estrogens were first used over-the-counter (OTC) to restore and maintain skin health, unwanted estrogenic side effects were linked to the use of these products. Safety concerns finally led to the removal of all estrogens and other hormone-containing OTC products in the US in 1994. Less than 10 years later, the use of estrogen-containing prescription products were associated with an increased risk of cancer and cardiovascular disease. These risks associated with estrogen use have made many doctors and patients hesitant to use estrogens to manage aging skin and vaginal atrophy associated with low estrogen.

Hygeia's biodegradable topical estrogens were specifically designed to avoid the risks associated with currently available estrogen products.

References-

  1. Rossouw JE. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the women's health initiative randomized controlled trial. JAMA 2002: 288(3): 321-333.
  2. Cushman M. Estrogen plus progestin and risk of venous thrombosis. JAMA 2004: 202(13) 1573-1580.
  3. Thornton, MJ. The biological actions of estrogen on the skin. Exp Derm 2002: 11: 487-502.
  4. Heldring N. et al., Estrogen receptors: How do they signal and what are their targets. Physiol Rev 2007: 87: 905-931.
  5. Levin ER. Cellular functions of plasma membrane estrogen receptors. Steroids 2002: 67: 471-475.
  6. Labrie, F. et al., Effect of one-week treatment with vaginal estrogen preparations on serum estrogen levels in postmenopausal women. Menopause 2009: 16(1): 30-36.
  7. SOGC Clinical Practice Guidelines- The detection and management of vaginal atrophy. International Journal of Gynecology & Obstetrics 2005: 88: 222-228.
  8. Wolff EF, Narayan D., and Taylor HS. Long-term effects of hormone therapy on skin rigidity and wrinkles. Fertility and Sterility 2005: 84(2): 285-288.
  9. Crosignani PG. Hormones and cardiovascular health in women. Human Reproduction Update 2006: 12(5) 483-497.
  10. Leclair DM and Anandarajah G. Effects of estrogen deprivation- vasomotor symptoms, urogenital atrophy, and phychobiological effects. Clinics in Family Practice 2002: 4(1): 27-39.
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